A quick note before we get started: This page was created to give visitors information about Simparica Trio for dogs and it’s benefits. But I realize many of you are here because you are looking for the best price for this amazing product.

If that’s the case for you, you can click on the banner right below (or to the right) to visit the website where we purchase all of our pet goods! They carry Simparica Trio starting from $59.99/3-month supply. Check them out and I promise you won’t be disappointed. 😉

And with that said, I’ll get back to the article!

A Guide on Simparica Trio for Dogs and its Benefits

Dogs are the most adorable creatures on earth, but keeping them as pets requires taking good care of them. This includes keeping them from being infested with nasty ticks and fleas. Or even worse, having them suffer from hookworm or roundworm infections.

Your vet will probably recommend that you use Simparica Trio for dogs to keep your pal protected from these troubling parasites. But what is the Simparica Trio, and how does it work? Will it be beneficial for your four-legged friend? Keep reading to find out. 

What is the Simparica Trio?

Simparica Trio is a veterinary medicine that treats your dog to prevent tick or flea infestations. It also works as a preventative for hookworm or roundworm infections in the gut.

Simparica Trio can also simultaneously be used to keep your dog from developing a lungworm or heartworm disease (which are often caused by blood worms infecting the blood vessels and heart supplying the lungs). You can also use it for treating flea allergy dermatitis.

How Does Simparica Trio Work?

Simparica Trio comprises three active substances, namely:

  • Sarolaner 
  • Moxidectin
  • Pyrantel

Sarolaner typically acts like an ectoparasiticide, meaning it will kill parasites (such as ticks and fleas) that are attached to the dog’s fur or skin. Sarolaner kills these nasty parasites that have fed on your dog’s blood by acting on its nervous system.

It will obstruct the normal movement of charged ions in (chloride particles) in and out of the nerve cells… particularly those associated with GABA (gamma-aminobutyric acid) and glutamate. These 2 substances mainly convey the signals amid the nerves.

This leads to the uncontrolled activity of the pest’s nervous system. The parasite will become paralyzed, followed quickly by their death. Sarolaner will also kill the fleas before they get a chance to lay their eggs. 

Moxidectin targets parasites like lungworms, hookworms, roundworms, and heartworm inside the animal’s body and kills them. It causes these parasites to be paralyzed and die by interfering distinctly to Sarolaner with the flow of chloride particles in nerve cells associated with glutamate and GABA.

Pyrantel also kills the hookworms and roundworms present inside your dog’s gut but behaves differently to Moxidectin. It blocks signals that are typically associated with the neurotransmitter acetylcholine all the way from your dog’s nerves to its muscles. As a result, this causes sudden contraction, followed by paralysis, and eventually death.

Benefits of Simparica Trio

For puppies and dogs aged 8 weeks and older and with a weight of 2.8 pounds or more, monthly Simparica Trio is the best treatment and means of prevention from numerous parasites. Here are some of the benefits of Simparica Trio backed by laboratory and field studies: 

● For flea prevention and treatment

In planned laboratory research, this particular medicine started to kill fleas in dogs in just 4 hours. It also demonstrated 100% efficacy within 8 hours after it was initially administered. 

● For tick control and treatment

Another well-controlled lab study demonstrated that Simparica Trio started killing deer ticks within 8 hours. 

● For prevention from heartworm disease

As depicted by 2 well-controlled lab studies, just one oral dose of the incredible Simparica Trio was known to show 100% effective results in preventing heartworm diseases from developing in dogs. 

● For intestinal parasite control and treatment

As demonstrated in a 10-day multi-center field study, this medicine showed effectiveness of 99.2% against adult roundworms. It also showed a significant decrease in fecal egg count. Lastly, the study revealed more than 94% effectiveness against hookworms too.

Where Is The Best Place to Get Simparica Trio?

As I spoke about at the top of this article, we’ve been getting our flea and tick prevention products from the same online store for the last few years! I checked, and you can get Simparica Trio without a prescription from them for a much better price than what you will pay at your local veterinarian. Their Simparica Trio cost starts at only $59.99 for a 3-month supply at their store. You can check it out here: